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Modafinil: Why You Should Be Aware of Its Side Effects

Modafinil: Why You Should Be Aware of Its Side Effects

Modafinil fell under the “Schedule IV controlled substance” classification, meaning that it can’t be legally purchased without the prescription from a physician. As stated by the United States Drug Enforcement Agency, the tablets under this classification are assumed to have a very low potential for abuse or physical dependence (addiction). Nonetheless, there does appear to be some study to recommend that Modafinil online India may have a potential for abuse and addiction. According to this documentation published by Teva Pharmaceuticals, 1/3 of participants in clinical studies documented experiencing headaches and nausea, while other negative side effects such as anxiety, dizziness, gastrointestinal problems, diarrhea, insomnia, and nervousness are reported.

Rare cases have been reported of more chronic side effects, including severe skin rashes and other symptoms that are potentially allergy-related. From the time of its manufacture, the US Food and Drug Administration received six reports of chronic side effects connected with Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), erythema multiforme (EM), and DRESS syndrome, involving the adult and pediatric patients. The FDA issued a critical warning. In the same alert, FDA also reported that multi-organ hypersensitivity reactions and angioedema have also been reported in post-marketing stages. In 2007, the FDA asked Cephalon to alter the Provigil leaflet in boldface print of numerous potentially fatal and serious disorders attributed to Modafinil use, including DRESS syndrome, SJS, and TEN. The long-term safety and effectiveness of Modafinil have not been recognized.

If you order Provigil, it may have a side effect on birth control and hormonal contraceptives for up to a month after discontinuation.

Modafinil: Why You Should Be Aware of Its Side Effects

Addiction and Dependence Potential 

The addiction and dependence potential of Modafinil use is low! It shares biochemical roles with addictive stimulant pills. Other studies have proved it to have similar mood-elevating natures, although to a lesser degree. Monkeys will self-administer these resources if they have previously been educated to self-administer cocaine. Even if Modafinil doesn’t produce reinforcing effects in mice at the dosage that’s equivalent to those used medically in human beings, it does so at higher doses. Although rare, cases of Modafinil abuse exist. Due to this, Modafinil fell under the “Schedule IV controlled substance” classification. This is the area for tablets with authorized medical uses and low but high addiction potential.

Psychological dependence upon Modafinil has only been found in case reports involving daily overdoses for an extended duration of time. Withdrawal symptoms include anxiety, lethargy, insomnia, and anhedonia.


Large-scale clinical studies have found no evidence of tolerance with Modafinil at medical doses even with prolonged use (with the span of 40 weeks to 3 years).

Psychiatric Reactions 

Modafinil-associated psychiatric responses have occurred in those with and without the pre-existing psychiatric history. As discussed, Modafinil use is becoming famous with students as the result of its concentration-enhancing abilities. This brand of use can result in more cases of people who take Modafinil being diagnosed with substance use disorder.

As a few study states, it has a low potential for addiction, Modafinil has been suggested as being potentially useful in treating people recovering from addiction to cocaine.